NOS3 may have an effect in the effectiveness of BDNF. G/G genotypes of NOS3 has been found in higher frequencies in faster triathletes.
Genetic predetermenants of athletic ability may explain some of the variance found by the association of aerobic fitness hypothesis.
"eNOS [NOS3] is associated with plasma membranes surrounding cells and the membranes of Golgi bodies within cells.” - wiki
Golgi Bodies: “It processes and packages macromolecules, such as proteins and lipids, after their synthesis and before they make their way to their destination; it is particularly important in the processing of proteins for secretion.” - wiki
Evolutionary importance on fighting induced exercise. Hunting can be considered fighting too, especially early in history -
use between subjects design to test several different modes of exercise on similar outcomes.
- Lower extrimity
- low-grade glioma
- Cultural Differences in the exercise /cog effect (e.g., BDNF) - Uncontacted tribes
age-related changes in perception, attention, and memory
look at exercise as charging a battery.
more time spent charging the battery will result in a bigger battery (fitness/strength gains). however, it’s the actual charge in the battery, not the size that predicts the increased psychological/cognitive benefits.
- those with larger batteries, may have a bit more residual charge - or they tend to spend more time exercising in general. that may account for some of the fitness differences we see.
Look at the effects of exercise on cognitive flexibility (language learning/code breaking/divergent thinking)